Can your total cholesterol level be too low?
Answer From Francisco Lopez-Jimenez, M.D.
A high blood cholesterol level increases your risk of coronary artery disease. Lower cholesterol is usually better, but in rare cases having a very low level of low-density lipoprotein (LDL, or “bad”) cholesterol or a very low total cholesterol level has been associated with some health problems.
Doctors are still trying to find out more about the connection between low cholesterol and health risks. There is no consensus on how to define very low LDL cholesterol, but LDL would be considered very low if it is less than 40 milligrams per deciliter of blood.
Although the risks are rare, very low levels of LDL cholesterol may be associated with an increased risk of:
- Hemorrhagic stroke
- Preterm birth and low birth weight if your cholesterol is low while you’re pregnant
The potential risk of lowering LDL cholesterol to very low levels has not been confirmed, and its association with certain health risks is still under debate.
Recent trials using novel treatments to lower cholesterol have reached extremely low cholesterol values with no increased risk for major side effects, but the follow-up was relatively short.
In some cases it is not clear if low cholesterol causes the health problem or if it’s the other way around. For example, people with depression may have low cholesterol levels, but it has not been proved that lowering cholesterol with statin therapy causes depression.
However, the benefits of lowering total and LDL cholesterol have been demonstrated extensively, particularly in individuals with heart disease or at high risk of heart disease or strokes.
If you’re concerned about your cholesterol level, consult your doctor. If you’re taking statins, don’t stop without first consulting your doctor. He or she can determine the cholesterol range most appropriate for you.
Francisco Lopez-Jimenez, M.D.
From Mayo Clinic to your inbox
Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health.
To provide you with the most relevant and helpful information, and understand which
information is beneficial, we may combine your email and website usage information with
other information we have about you. If you are a Mayo Clinic patient, this could
include protected health information. If we combine this information with your protected
health information, we will treat all of that information as protected health
information and will only use or disclose that information as set forth in our notice of
privacy practices. You may opt-out of email communications at any time by clicking on
the unsubscribe link in the e-mail.
Thank you for subscribing!
You’ll soon start receiving the latest Mayo Clinic health information you requested in your inbox.
Sorry something went wrong with your subscription
Please, try again in a couple of minutes
- Arcus senilis: A sign of high cholesterol?
- Cholesterol ratio or non-HDL cholesterol: Which is most important?
Nov. 17, 2022
- Moayeri M, et al. Maternal lipid profile and the relation with spontaneous preterm delivery: A systematic review. Archives of Gynecology and Obstetrics. 2017;295:313.
- Catapano AL, et al. 2016 ESC/EAS Guidelines for the management of dyslipidaemias. Atherosclerosis. 2016;253:281.
- Faselis C, et al. Is very low LDL-C harmful? Current Pharmaceutical Design. 2018;24:1.
- Cenik B, et al. Plasma sterols and depressive symptom severity in a population-based cohort. PLoS One. 2017;12:e0184382. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184382. Accessed Oct. 29, 2018.
- Hypolipidemia. Merck Manual Professional Version. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/lipid-disorders/hypolipidemia. Accessed Oct. 26, 2018.
- What your cholesterol levels mean. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/what-your-cholesterol-levels-mean. Accessed Oct. 29, 2018.
- Lopez-Jimenez F (expert opinion). Mayo Clinic. Rochester, Minn. Nov. 6, 2018.
- Olsson AG, et al. Can LDL cholesterol be too low? Journal of Internal Medicine. 2017;281:534.
- Jorgensen D, et al. Higher dietary inflammation is associated with increased odds of depression independent of Framingham Risk Score in the National Health and Nutrition Examination Survey. Nutrition Research. 2018;54:23.